Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients

Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in populations geographic areas. Herein, we determined the spectrum Iranian MDS patients for first time. Methods This prospective cross-sectional study was conducted on 103 with Ahvaz, southwest Iran, from 2014 2018. Clinical presentations, complete blood counts (CBC), bone marrow (BM) biopsy samples were assessed. Perls' staining used evaluate BM iron storage. The evaluation performed using conventional G banding method BM. Results Patients’ median age 62.3 (ranged 50–76), majority male (72.8%). most common clinical symptom at time admission fatigue (n = 33) followed by pallor 27). subgroup MDS-Multi Lineage Dysplasia (MDS-MLD) 38, 36.8%), MDS-Single (MDS-SLD) 28, 18.4%). A normal karyotype observed 59 (57.3%), while 44 (42.7%) had abnormalities. Trisomy 8 (+ 8) abnormality 14) del 17p 9) monosomy 7 (? 7) 7). Twelve (11.65%) transformed AML. Conclusion Our data betokened that among our patients, is predominant abnormality, MDS-MLD MDS-SLD are subtypes. Noteworthy, male: female ratio slightly higher Iran than previous reports other parts world. report clinical, hematological,